Semen A. Leyn
Ph.D. student

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Scientific interests:

- reconstruction of regulatory networks and metabolic pathways in bacteria
- identification of transcription factor-binding sites in bacterial genomes using comparative approach
- evolution of regulation in bacteria

Education:

2009-present. Institute for information transmission problems of the Russian Academy of Sciences, Ph.D. Student
2003-2009: D. Mendeleyev University of Chemical Technology of Russia, M.S.

Research experience:

2009-present: Institute for Information Transmission Problems of the Russian Academy of Sciences
2010.05 2010.06. Lawrence Berkeley National Laboratory (Berkeley, USA)
2006-2009. The Bach Institute of Biochemistry

Publications:


Novichkov PS, Kazakov AE, Ravcheev DA, Leyn SA, Kovaleva GY, Sutormin RA, Kazanov MD, Riehl W, Arkin AP, Dubchak I, Rodionov DA. RegPrecise 3.0 -- A resource for genome-scale exploration of transcriptional regulation in bacteria. BMC Genomics. 2013 Nov 1;14(1):745. PubMed  PDF

Sun EI, Leyn SA, Kazanov MD, Saier MH Jr, Novichkov PS, Rodionov DA. Comparative genomics of metabolic capacities of regulons controlled by cis-regulatory RNA motifs in bacteria. BMC Genomics. 2013 Sep 2;14:597.PubMed  PDF

Leyn S.A., Kazanov M.D., Sernova N.V., Ermakova E.O., Novichkov P.S., Rodionov D.A. Genomic Reconstruction of the Transcriptional Regulatory Network in Bacillus subtilis. J Bacteriol 2013 195(11): 2463-2473. PubMed  PDF

Ravcheev D.A., Li X., Latif H., Zengler K., Leyn S.A., Korostelev Y.D., Kazakov A.E., Novichkov P.S., Osterman A.L., Rodionov D.A. Transcriptional regulation of central carbon and energy metabolism in bacteria by redox-responsive repressor Rex. J Bacteriol 2012 194(5): 1145-1157. PubMed  PDF

Leyn S.A., Li X., Zheng Q., Novichkov P.S., Reed S., Romine M.F., Fredrickson J.K., Yang C., Osterman A.L., Rodionov D.A. Control of proteobacterial central carbon metabolism by the HexR transcriptional regulator: a case study in Shewanella oneidensis. J Biol Chem 2011 286(41): 35782-35794. PubMed  PDF

Conferences:

The 5th International Moscow Conference on Computational Molecular Biology, MCCMB-2011. Moscow. Russia, 21-14.07.2011
S.Leyn, M.Kazanov, P.Novichkov, D.Rodionov Reference collection of transcriptional regulons in Bacillales family of bacteria (poster)

The 110th General Meeting of the American Society for Microbiology
D.A. Rodionov, X. Li, A. Osterman, S. Leyn. Comparative and Functional Genomics of the Central Carbon Metabolism Regulon HexR in Proteobacteria.

Information Technologies and Systems (ITaS '09), Bekasovo, Russia.
Leyn S.A., Ravcheev D.A. Evolution of chimeric protein: AraR dependent regulation research by comparative genomics methods.